Although the possibilities of what induced pluripotent stem cells are very great, there are some problems with them. One possible problem with them is that the transcription factors do not completely turn on causing the cell to not be fully pluripotent and work properly. This also causes more issues because an induced pluripotent stem cell that is not fully matured can cause cancer if it is used. Other issues with induced pluripotent stem cells are that using a virus to insert the transcription factors in the somatic cells can cause the virus to be encrypted in the cell’s DNA and cause the cell to be more prone to cause cancer and not work properly as a pluripotent stem cell. Another problem is that the somatic cell retains gene expressions that are specific to the type of cell it originally was. The cell retains the memory of the original type of tissue it was and this sometimes causes issues causing the embryonic genes to not be completely expressed. This causes the cell to work improperly as a pluripotent stem cell. Because it has been found that not using the c-Myc transcription factor, there have been set backs that occur from not using the c-Myc. Not using the c-Myc transcription factor makes the process of developing the induced pluripotent stem cells longer and yields fewer cells. Also, although the risk of cancer forming is less, it is still very possible to form if the cell was genetically modified. The other problem with induced pluripotent stem cells is that they tend to age prematurely and have a high rate of apoptosis. This makes them unreliable to use until more is known on how to prevent this from occurring.